When I first saw the ending of Texhnolyze (around 2005ish, I was still a young teenager), while the scene with Ran was unfolding I unconsciously dug my fingers into the skin of my other arm and drew blood. I was making the same facial expression of confusing and rage that Ichise was making and I started sweating and crying intensely. Then the scene that immediately followed afterwards with the insert song and I fucking bawled like a bitch.
I threw up later that evening too.
Not a single other anime or any other piece of media gave me such a visceral reaction, jesus christ. I haven't watched Texhnolyze since then and I don't want to watch it again.